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Advanced Therapeutics: Spirulina hydrogel in the treatment of bacterial infected wounds - dual effects on regulating wound hypoxia and photodynamic bactericidal action

wallpapers News 2020-10-19

skin is a natural barrier of human immune system protecting the body from various threats of the external environment. Once damaged the wound will become a "shortcut" for pathogens to invade the human body causing a variety of infectious diseases even death. At the same time the emergence of multi drug resistant bacteria makes the use of antibiotics become cautious. Therefore the research development of non antibiotic antibacterial wound healing therapy has become a hot area of scientific research. Oxygen participates in important physiological activities such as immune response cell proliferation angiogenesis in the process of wound healing. It has been an effective strategy to deliver exogenous oxygen to the wound area with insufficient oxygen supply due to vascular rupture contraction such as hyperbaric oxygen therapy local oxygen therapy. However its clinical application is still limited due to the high price complex operation steps in the treatment process. In view of this the Zhou Min research group of the Second Affiliated Hospital of Zhejiang University affiliated to the Institute of translational medicine has prepared a kind of active hydrogel with photosynthetic oxygen production antibacterial activity by simple one-step synthesis. The hydrogel with active Spirulina as the core encloses the carboxymethyl chitosan shell with good biocompatibility which can continuously release dissolved oxygen successfully improve the hypoxia microenvironment at the wound. At the same time the chlorophyll of Spirulina has the function of photodynamic sterilization which can achieve the dual therapeutic effects of antibacterial healing.

spirulina as a kind of microalgae with great potential of biotechnology has been widely used in sewage purification medical research biofuel production other fields. As an edible dietary supplement or whole food it has been widely commercialized has good biological safety medical potential. Researchers believe that Spirulina is a potentially effective drug for clinical application. It is rich in chlorophyll can produce a large amount of dissolved oxygen under light which can promote wound healing. At the same time chlorophyll as a natural photosensitizer can produce living oxygen under laser irradiation which can effectively kill the bacteria around the wound to protect the wound from bacterial invasion. The study used carboxymethyl chitosan a commonly used hydrogel dressing with excellent biocompatibility broad-spectrum antimicrobial activity to encapsulate spirulina to improve its adhesion to infected wounds. Spirulina hydrogels smeared on wounds can improve wound hypoxia microenvironment high bactericidal performance under light irradiation play a dual therapeutic role in wound healing. Therefore the spirulina hydrogel has many advantages such as high efficacy good safety easy batch production low price convenient portability has great potential for clinical application.

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