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Advanced therapeutics: gold nanourchins for photothermal chemotherapy and photoacoustic Raman imaging

wallpapers News 2020-08-29

chemotherapy is widely used in cancer treatment. Due to the side effects drug resistance the curative effect is often unsatisfactory. The rise of nano biomaterials provides a new possibility for targeted controlled release of antitumor drugs. At the same time the introduction of hyperthermia is expected to improve consolidate the anticancer effect of single chemotherapy. In recent years photothermal agents based on nano materials have been widely developed among which near-infrared laser-induced photothermal conversion has attracted much attention due to its non-destructive high penetrability. Gold nanomaterials can not only be used for drug loading but also can generate heat by near-infrared irradiation. Moreover the reaction conditions are mild functional modification is easy the biological stability is excellent so it is one of the ideal nano photothermal agents.

benefit from their unique photophysical properties. Gold nanomaterials have excellent application prospects in the field of surface enhanced Raman spectroscopy (SERS) imaging. The signal of Raman image comes from Raman probe molecular vibration spectrum. On the spiny gold nanostructures the intense electromagnetic field generated by plasmon effect can enhance the surface Raman scattering then significantly amplify the spectral signal of the probe molecules on the gold surface. It depends on the "embedding" of exogenous probe molecules to track the enrichment state of gold nanomaterials in tumor site with high signal-to-noise ratio. In addition the combination of Raman photoacoustic imaging breaks through the shortcomings of traditional optical imaging in terms of depth resolution achieves specific sensitive depth imaging.

a new type of gold nano sea urchin was synthesized by Hongjun Wang research group of Stevens Institute of technology using polymer micelles as soft template. The functionalized gold nano sea urchin can efficiently load adriamycin (DOX) through π - π conjugation. Raman probe 4-mpba is bonded to aunus surface by Au-S which makes it have the function of Raman report. At the same time 4-mpba connects with dopamine to provide ATP responsive borate bond then hyaluronic acid (HA) is coated on the surface through amide bond. The nano system can actively target tumor cells with high expression of CD44 trigger drug release under the action of high expression of hyaluronidase (HAase) ATP in tumor area. In vivo in vitro studies showed that AuNUs-HA@DOX Nano system can be used in photothermal chemotherapy photoacoustic Raman imaging.

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