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View: Research Progress of metal oxide nanoparticles in bacterial tracing and antibacterial application

wallpapers News 2020-12-07

antibiotic resistance is an important hidden danger threatening human health in the world. It is expected to find a new type of antibacterial nano preparation which is not easy to induce drug resistance to solve the problem in the game between human bacteria. In recent years metal oxide nanoparticles with unique antibacterial properties is one of the hot research fields. This kind of nanoparticles can not only show good application value in bacteria tracing by virtue of their inherent or surface functionalized imaging characteristics but also interfere with the normal life activities of bacteria by acting on the cell membrane cell wall or cell contents of bacteria also produce reactive oxygen substances resulting in strong oxidative stress damage to cells. Therefore metal oxide nanoparticles have attracted much attention in antibacterial applications which has been proved to be one of the directions with great development potential.

scheme: the metal oxide nanoparticles have intrinsic capacity in antibacterial stewardship. In

we first analyzed the antibacterial mechanism of metal oxide nanoparticles. Because of its non-specific mechanism low mutagenic potential it is toxic to almost all microorganisms. It can replace antibiotics to kill bacteria is not easy to induce resistance. Then the effects of physicochemical properties (particle size morphology surface charge solubility aggregation dispersion crystal structure) of metal oxide nanoparticles on their antibacterial properties were discussed. Then the author focuses on some excellent modification strategies to reduce the potential biological toxicity of the nanoparticles improve their antibacterial properties so as to provide reference for the design preparation of metal oxide nano antibacterial agents with excellent performance. Finally the application of metal oxide nanoparticles in the diagnosis of bacterial infection is emphasized. Although the related research is still in the primary stage of development most of which are limited to magnetic Fe3O4 nanoparticles it has been proved that it has a broad development prospect. In the study of bacterial infectious diseases we should not only pay attention to the development of new antibacterial drugs but also realize the rapid diagnosis of early infection as far as possible. According to the principle of targeted reasonable infection control we should implement multi pronged treatment so as to overcome the problems of traditional antibiotic resistance. The metal oxide nanoparticles introduced in this paper are expected to be large in the "post antibiotic era" To achieve the integration of diagnosis treatment.

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